SPECTRUS Webserver

Structure's cover This web server performs a decomposition into quasi-rigid domains of proteins or protein complexes, based on the analysis of the distance fluctuations between pairs of amino acids. A detailed description of the algorithm is provided in Ponzoni L, Polles G, Carnevale V, Micheletti C, "SPECTRUS: a dimensionality reduction approach for identifying dynamical domains in protein complexes from limited structural datasets", Structure, 2015 .

The server processes entries of up to 2000 amino acids and trajectory files of up to 50MB. If your data exceed this limit, please consider to run SPECTRUS locally on your machine by installing the source code available here.

Note: if a single pdb code/structure is provided, the subdivision will be based on ENM calculation.

Upload one or more protein conformers in pdb/xyz format (?):
Insert pdb codes of conformer(s)
e.g.: 1akeA, 4akeA (?):
Your email (to send you the link to your job results - optional):

Parameters:

Minimum number of domains:
Maximum number of domains:
Iterations of the k-medoids algorithm:
Nearest neighbors cutoff (Å):