SPECTRUS-evo Webserver

This web server performs a decomposition of a protein sequence into evolutionarily-related domains, based on the analysis of coevolutionary couplings between pairs of amino acid positions in a multiple sequence alignment. A detailed description of the algorithm is provided in: Granata D, Ponzoni L, Micheletti C, Carnevale V, "Patterns of coevolving amino acids unveil structural and dynamical domains", PNAS, 2017. Access the recommendation on F1000Prime

Upload a file containing the statistical couplings between residues:
Reference PDB structure (optional):
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Run example
(adenylate kinase)


Minimum number of domains:
Maximum number of domains:
Iterations of the k-medoids algorithm:
Nearest neighbors number:
Sequence connectivity:
Similarity matrix preprocessing: